Global Ganja Report

The Green Wolverine conference at the University of Michigan this month will bring speakers from across the country for a symposium on cannabis science. With Michigan facing a legalization initiative this November, the student-organized event is intended, among other things, to help voters make an informed choice.

Having just undertaken a "critical study" of CBD, the non-psychoactive cannabinoid held to have multifarious medicinal applications, the World Health Organization is now opening such a study on THC. Stigmatized due to its psychoactive properties and currently in the shadow of the suddenly sexy CBD, tetrahydrocannabinol shows its own potential for application by the medical industry.

A new product is being plugged as containing CBD derived from humulus—that is, hops, the buds used as a bittering agent in beer. Some of the media hype has implied that this novel origin gets around the US federal stricture on the cannabinoid. But experts raise a skeptical eyebrow at the claim of hops-derived CBD. And in any event, the federal stricture is on the cannabinoid itself, regardless of how it is derived. 

California health authorities dealt a blow to the burgeoning CBD business by banning preparations of the cannabinoid derived from industrial hemp rather than psychoactive cannabis. The diktat adds to the legal confusion around CBD, and highlights the need for greater clarity from the competent authorities at both the state and federal level.

For a generation now, science has known of two cannabinoid receptors—specialized protein molecules that interact with the active compounds in the cannabis plant for the human body. These are CB1 and CB2, both discovered in the early '90s. Now there is growing awareness of a third such receptor that was identified in 2007. This receptor, GPR55, may be key to understanding a wide spectrum of therapeutic applications for cannabinoids—and especially the non-psychoactive cannabidiol, or CBD.

Something of a corporate scramble is underway to secure patents for the various curative properties of CBD, and associated products and procedures. Pharmaceutical firms see a windfall, but some activists raise concerns about the creeping privatization of a cannabinoid that should belong to the genetic and intellectual commons of the human race. How realistic are fears about the imminent arrival of "corporate cannabis"?

A federal appeals court has turned down a challenge by the cannabis industry to the DEA's official finding that CBD is a controlled substance. But questions about whether CBD should be treated as a controlled substance remain pending at the state level.

A recent study about the impact of cannabinoids on bone density is raising concerns about possible ill effects on longterm heavy marijuana smokers. Earlier studies, however, showed potential for certain cannabinoids in treating bone fractures. The relationship between cannabis and bone-building function may be more complicated than recent media reports suggest.